Miscarriage is the most common complication during the early stages of pregnancy and occurs in about 15-25% of
clinically diagnosed pregnancies, most of which in the first trimester of gestation.
There are many known causes and risk factors for spontaneous abortion but about 60% of cases originate from
Diagnosing a chromosomal abnormality as a cause of miscarriage provides important information for predicting
the risk of recurrence and helps identify familial chromosomal rearrangements that can predispose couples to
recurrent miscarriages or the birth of babies with congenital abnormalities and / or intellectual disabilities.
In 2016, the American College of Obstetricians and Gynecologists (ACOG) and the Society for Maternal-Fetal Medicine
recommended the search for chromosomal abnormalities on the placenta, amniotic fluid and the product of
conception (POC) in cases of intrauterine fetal death and perinatal mortality 3.