POCADAVANCE cfDNA Test is an advanced molecular test that, using groundbreaking technologies, determine the karyotype of
product of conception (POC). By analyzing the circulating
cell-free fetal DNA (cfDNA) in maternal blood, using the latest fully automated sequencing technologies (Next Generation Sequencing - NGS), it screens for genome-wide numerical and structural chromosomal abnormalities, providing unparalleled accuracy and detection compared to traditional karyotyping. POCADAVANCE cfDNA Test is able to provide information on the possible genetic causes of a spontaneous miscarriage, with the aim of helping the couple in family planning with specific reproductive genetic counseling.
During pregnancy, placental trophoblasts, through a physiological process known as apoptosis, releases DNA fragments into the maternal blood, starting from the 5th week of gestation. This DNA is also named circulating cell-free fetal DNA (cfDNA).
During miscarriage, the placental tissue continues to release cfDNA into the maternal bloodstream, making it possible to perform early non-invasive investigations, thus obtaining valuable information on the genetic causes of the abortion.
4 Yaron et al., 2020
5 Colley et al., 2020
6 Hartwig et al. 2023