POCAdvance Tissue KARYO
POCAdvance Tissue KARYO is an advanced genetic test that enables determination of the molecular fetal karyotype directly from miscarriage tissue (product of conception – POC).
The test uses high-sensitivity, high-resolution massively parallel sequencing technologies (Next Generation Sequencing – NGS), enabling detection of fetal chromosomal alterations that may be responsible for the miscarriage event.
The primary clinical objective is to provide genetically relevant information on the causes of pregnancy loss, supporting the couple’s reproductive genetic counseling and family planning.
Test specifications
Advantages over traditional methods
POCAdvance Tissue KARYO overcomes the main limitations of conventional cytogenetic karyotyping, offering significant technical and clinical benefits.
No cell culture required
Eliminates the risk of culture failure and non-informative results, a frequent limitation of conventional techniques.
Maternal cell contamination exclusion
The genetic profile of the POC sample is compared with the maternal profile, ensuring analytical specificity for fetal DNA origin.
High resolution
Detects microdeletion and microduplication syndromes >1 Mb, compared with the ~10–15 Mb threshold of traditional cytogenetic karyotyping.
Rapid turnaround time
Results available in approximately 5 working days from sample receipt, for a timely diagnosis.
Interpretation of results
Chromosomal abnormality detected
A numerical and/or structural chromosomal abnormality has been identified in the fetal karyotype. The result provides information on the causes of the miscarriage event and supports reproductive genetic counseling.
No chromosomal abnormality detected
No chromosomal abnormalities were identified; the fetal profile is compatible with a euploid karyotype. Further clinical evaluation is recommended to identify other possible causes.
Test indications
POCAdvance Tissue KARYO is indicated in the following clinical scenarios:
- Miscarriage in women who wish to obtain a genetic characterization of the product of conception.
- Repeated pregnancy losses in the absence of an exhaustive clinical explanation.
- History of recurrent miscarriage, to identify possible recurrent chromosomal alterations.
How to order the test
request
completion
collection
shipment
delivery
Sample types required for test execution
Brochure
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